Systolic hypertension related single nucleotide polymorphism is associated with susceptibility of ischemic stroke

L.-L. Zhong, L.-S. Ding, W. He, X.-Y. Tian, H. Cao, Y.-Q. Song, L. Yu, X.-Y. Sun

Department of Hematology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, Jiangsu, P.R. China. yuliangha@163.com

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• Neurology

OBJECTIVE: Isolated systolic hypertension (ISH) is the most important risk factor for ischemic stroke. Genetic variants influencing hypertension can also be risk factors for ischemic stroke. Here, we examined the how single nucleotide polymorphisms (SNPs) associated with blood pressure impact the risk for ischemic stroke.

PATIENTS AND METHODS: We selected 300 ischemic stroke patients and 300 controls. Then, we genotyped three single nucleotide polymorphisms associated with systolic hypertension in both groups.

RESULTS: Logistic regression analysis showed that the rs11099098 genotype was associated with a significantly decreased risk of IS (Dominant model: OR = 0.55, 95% CI = 0.37-0.82, p = 0.003). Two other SNPs, rs880315 and rs11072518, showed a trend towards association with stroke risk, but did not reach statistical significance.

CONCLUSIONS: Our study suggests that genetic variants in systolic pressure-related genotypes may contribute to the etiology of ischemic stroke.

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