Study on the effect of Integrin αVβ6 on proliferation and apoptosis of cervical cancer cells

D. Liang, W. Xu, Q. Zhang, B.-B. Tao

Department of Gynecology and Obstetrics, Women and Infants Hospital of Zhengzhou, Zhengzhou, Henan Province, China. 2317952701@qq.com

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• Oncology

OBJECTIVE: To analyze the influence of Integrin αVβ6 on proliferation and apoptosis of cervical cancer cells.

PATIENTS AND METHODS: Fifty-two patients with benign cervical lesions, 55 cervical cancer patients, and 20 healthy controls were selected as research subjects. The positive expression rate of Integrin αVβ6 was detected in cervical tissue samples by immunohistochemistry. The relative expressions of the proliferation-related proteins, p53, PCNA, Ki-67, and TIPE2, and the apoptosis-related proteins, Cyto-C, AIF, caspase-3, Bag-1, Bcl-2, and p-Akt were measured by Western blot.

RESULTS: The positive rate of Integrin αVβ6 expression was higher in tissue from cervical cancer patients than in the other two groups (p < 0.05). The levels of expression of p53, PCNA, and Ki-67 in the cervical cancer group were higher, while the levels of TIPE2 were lower compared with the other two groups (p < 0.05). The levels of expression of Bag-1 and Bcl-2 were higher in the cervical cancer group, but Cyto-C, AIF, caspase-3, and p-Akt were lower compared with the other two groups (p < 0.05). Compared with cervical cancer patients with negative Integrin αVβ6 expression, patients with positive Integrin αVβ6 expression had different expression levels of the proliferation- and apoptosis-related proteins, and the differences were statistically significant (p < 0.05).

CONCLUSIONS: High expression of Integrin αVβ6 is an important cause of active proliferation and impaired apoptosis in cervical cancer. Integrin αVβ6 is a promising target for the treatment of cervical cancer.

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