Influence of screening and intervention of hyperthyroidism on pregnancy outcome

Y. Wang, X.-L. Sun, C.-L. Wang, H.-Y. Zhang

Department of Galactophore Surgery, Weifang People’s Hospital, Weifang, China. 383719546@qq.com

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• Pharmacology

OBJECTIVE: To discuss the influence of screening and intervention of hyperthyroidism on pregnancy outcome.

PATIENTS AND METHODS: The clinical data of 122 pregnant women who had been confirmed with hyperthyroidism from April 2012 to July 2014 in the Weifang People’s Hospital were analyzed retrospectively (25 untreated, 97 treated). 60 with normal pregnancy check were randomly selected as control group. The pregnancy outcomes of the two groups of patients were analyzed.

RESULTS: Among 10,427 pregnant women, 122 of them were diagnosed with hyperthyroidism, the prevalence of hyperthyroidism and subclinical hyperthyroidism were 0.44% and 0.73%. The occurrence of adverse maternal, obstetric complication, and adverse perinatal infant of the untreated group was higher than that of the treated group, and the inter-group differences were of statistically significance (p<0.05). However, the comparison of treated group and control group showed that there was no statistical significance in occurrences of adverse maternal, obstetric complication, and adverse perinatal infant (p>0.05).

CONCLUSIONS: Timely screening for gestational thyroid disease and actively intervention treatment can significantly improve the outcome of pregnancy.

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