Eur Rev Med Pharmacol Sci 2017; 21 (8): 1768-1773

The structure and functions of paxillin and its roles in neovascularization

W.-J. Yang, J. Zhong, J.-G. Yu, F. Zhao, Y. Xiang

Department of Ophthalmology, Key Laboratory for Molecular Diagnosis of Hubei Province, the Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China. xiangyihel@sina.com

Identifying and studying the molecular mechanisms of neovascularization biomarkers are critical for conquering many diseases, such as corneal diseases and cancer. Paxillin is an important cell scaffold and cellular signaling protein, especially a key molecule of the Integrin-mediated downstream signaling transduction. This review summarizes the structure and functions of paxillin, and the research progress of its roles in neovascularization. Although there are still some problems to be solved, paxillin may become an important target of anti-neovascularization therapies.

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To cite this article

W.-J. Yang, J. Zhong, J.-G. Yu, F. Zhao, Y. Xiang
The structure and functions of paxillin and its roles in neovascularization

Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 8
Pages: 1768-1773

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