The polymorphism of XRCC1 and coronary artery disease risk: a meta-analysis

S.-J. Guo, Y.-T. Zhou, W.-Y. Liu, Q.-N. Zuo, X.-H. Li

The Affiliated Hospital of University of Electronic Science and Technology of China, Internal Medicine of Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China. shujinguo@126.com

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• Cardiology

OBJECTIVE: Coronary artery disease (CAD) is a life-threatening disease and is caused by various factors, with genetic variation being an important risk factor. The association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and CAD has been extensively studied with conflicting results. We performed a meta-analysis to investigate the overall association between XRCC1 polymorphisms and CAD risk.

MATERIALS AND METHODS: We searched PubMed and Embase databases until October 19, 2016. The total number and distribution of genotypes, genotyping methods, and ethnicity were extracted. Overall and subgroup analyses were performed.

RESULTS: A total of seven publications involving 1.862 subjects and 1.568 controls were included in this meta-analysis. The Arg399Gln and Arg194Trp polymorphisms of XRCC1 were analyzed. The results indicated that the XRCC1 Arg399Gln homozygous GG genotype showed no association with CAD risk [GG vs. GA+AA: odd’s ratio (OR) = 0.95, 95% confidence interval (CI) = 0.82-1.11, p = 0.53] both in the overall and subgroups evaluation. However, the XRCC1 Arg194Trp homozygous TT genotype was associated with an increased CAD risk [(TT vs. TC+CC: OR =1.52, 95%CI = 1.16–2.00, p=0.003)]. Subgroup analysis based on ethnicity showed a significant increase in the association of CAD risk and the Arg194Trp gene polymorphism among the Asian population.

CONCLUSIONS: This meta-analysis suggested that TT genotype in the Arg194Trp polymorphism contributes to the CAD susceptibility, particularly in the Asian population.

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