Hepatoprotective activity of Allium paradoxum

S.M. Nabavi 1, 2, A. Hajizadeh Moghaddam 3, M. Fazli 4, R. Bigdellou 5, S. Mohammadzadeh 6, S.F. Nabavi 1,2, M.A. Ebrahimzadeh 7

1 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran (Iran)

2 National Elites Foundation of Iran, Tehran (Iran)

3 Department of Biology, University of Mazandaran, Babolsar (Iran)

4 Student Research Development Committee, Mazandaran University of Medical Sciences, Sari (Iran)

5 Department of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz (Iran)

6 Department of Biology, University of Mohaghegh Ardabili, Ardabil (Iran)

7 Thalassaemia Research Center and School of Pharmacy, Mazandaran University of Medical Sciences, Sari (Iran)

---

• Phytomedicine

OBJECTIVES: Recent studies show that free radicals are important mediators of hepatic injury induced by carbon tetrachloride. Allium (A.) paradoxum showed antioxidant and antihemolytic activities. This work was conduct to determine the possible protective effect of this plant against hepatotoxicity.

MATERIALS AND METHODS: Subcutaneous injection of 3 ml/kg carbon tetrachloride diluted in olive oil (1:1 dilution) was employed for inducing acute liver toxicity. The protective effect of aerial parts and bulbs of A. paradoxum at flowering stage were determined.

RESULTS: Both aerial parts and bulbs extracts at the doses 500 and 750 mg/kg, i.p. offered significant hepatoprotective effect by reducing the serum marker enzymes, serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Histopathological studies further confirmed the hepatoprotective activity of aerial parts and bulbs extracts when compared with the CCl4 treated groups.

CONCLUSIONS: Extracts of A. paradoxum showed significant hepatoprotective activity compared with control group.

Corresponding Author: Mohammad Ali Ebrahimzadeh, Ph.D; e-mail: zadeh20@yahoo.com

Published on: 2012/10/17

Free PDF Download