Eur Rev Med Pharmacol Sci 2017; 21 (1): 55-60
DOI:

Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells

S. Shen, J.-X. Tang

Department of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, China. sx9l58@163.com

OBJECTIVE: The purpose of this study was to investigate the effect of the heparanase inhibitor OGT2115 on the tumorigenic properties of KB oral cancer cells.

MATERIALS AND METHODS: We treated KB cells with different concentrations of OGT2115. Then proliferation, invasion, and migration were detected using different assays. Cell cycle was explored using flow cytometry.

RESULTS: We found that the treatment inhibited proliferation, invasion, and migration in a dose-dependent manner. OGT2115 also increased the apoptosis of KB cells and blocked cell cycle in S-phase.

CONCLUSIONS: Our results support the use of the heparanase inhibitor OGT2115 to inhibit several tumorigenic activities of KB oral cancer cells.

This article has been withdrawn. The Publisher apologizes for any inconvenience this may cause.
Free PDF Download

To cite this article

S. Shen, J.-X. Tang
Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells

Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 1
Pages: 55-60
DOI:

Keywords Related articles:

  1. Mechanisms of OGT2115 inhibition of invasion and migration in KB oral cancer cells
  2. LncRNA BLACAT1 regulates the viability, migration and invasion of oral squamous cell carcinoma cells by targeting miR-142-5p
  3. IL-37 suppresses migration and invasion of gallbladder cancer cells through inhibition of HIF-1α induced epithelial-mesenchymal transition
  4. Long non-coding RNA CCAT1 promotes the migration and invasion of prostate cancer PC-3 cells
  5. BNIP1 inhibits cell proliferation, migration and invasion, and promotes apoptosis by mTOR in cervical cancer cells