Phosphodiesterase-5 inhibitors may facilitate bone defect recovery

F. Yaman, S. Atilgan, N. Günes, S. Agacayak, A. Günay*, M.C. Ucan, S. Bakir**, B. Erol, I. Kose, Y. Atalay

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Dicle, Diyarbakir (Turkey)
*Department of Periodontology, Faculty of Dentistry, University of Dicle, Diyarbakir (Turkey)
**Department of Ear Nose and Throat, Faculty of Medicine, University of Dicle, Diyarbakir (Turkey)

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• Pharmacology

Background and Objectives: Bone healing is still one of the most important problems of the oral and maxillofacial surgery procedures. This study was designed to evaluate the effect of sildenafil citrate (which is used for erectile dysfunction) on bone defect healing in an experimental animal model.

Materials and Methods: A total of 42 male Wistar-albino rats were randomly assigned to the control group (n=21) or the study group (n=21). The control group was fed on a standard laboratory diet until 12 h before surgery, whereas the study group received Sildenafil citrate via orogastric tube 10 mg/kg once a day for 30 days. Under anaesthesia, a 3x3x2 mm depth defect was made on tibia of each rat. 7 animals from each group were euthanised on postoperative days 7,15 and 30. Bone samples were taken for examination, histologically on day 7, by 3D dental tomography on day 15, and for bone strength resistance on day 30.

Results: Statistically significant differences were determined between the groups from the inflammatory and repair phase, with the healing process being more advanced in the Sildenafil group.

Conclusions: Sildenafil citrate can be used as a supporting factor to accelerate the healing process of bone. In future comprehensive studies will need to demonstrate the Sildenafil citrate affect on bone defect healing.

Corresponding Author: Ferhan Yaman, MD; e-mail: dtferhan@hotmail.com

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