Long non-coding RNA HNF1A-AS1 up-regulation in non-small cell lung cancer correlates to poor survival

Y.-F. Ma, T. Liang, C.-R. Li, Y.-J. Li, S. Jin, Y. Liu

Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China. sunnny301@126.com

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• Oncology

OBJECTIVE: Accumulating studies have focused on the role of the newly identified lncRNAs in the tumor. We aimed to investigate the clinical correlation between long non-coding RNA HNF1A-AS (HNF1A-AS1) expression and non-small cell lung cancer (NSCLC).

PATIENTS AND METHODS: Real-time polymerase chain reaction (PCR) was employed to detect HNF1A-AS expression in NSCLC tissues and corresponding adjacent tissues. The c2-test was used to compare the clinicopathological characteristics between different groups. Survival analysis was performed using the Kaplan-Meier method. The univariate and multivariate analyses were performed to investigate the prognostic significance of HNF1A-AS for NSCLC.

RESULTS: The level of HNF1A-AS was higher in tumor tissues than that in normal tissues (p < 0.01). In addition, HNF1A-AS level was significantly associated with TNM stage (p = 0.002) and Lymph node metastasis (p = 0.005). Kaplan-Meier analysis indicated that a high level of HNF1A-AS expression predicted unfavorable overall survival (p < 0.001). The univariate and multivariate analysis identified HNF1A-AS as an independent poor prognostic factor for overall survival in NSCLC patients (p < 0.05).

CONCLUSIONS: These results demonstrated that overexpression of HNF1A-AS might act a poor prognosis indicator in patients with NSCLC.

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