The role of glutamine supplemented total parenteral nutrition (TPN) in severe acute pancreatitis

X. Liu, X.-F. Sun, Q.-X. Ge

Department of Gastroenterology, Henan University Huaihe Hospital, Kaifeng, Henan, China. liuxin26@126.com

---

• Pharmacology

OBJECTIVE: To evaluate the role of glutamine-supplemented total parenteral nutrition (TPN) in severe acute pancreatitis.

PATIENTS AND METHODS: Forty-seven patients with severe acute pancreatitis were admitted to Huaihe Hospital, China, over a period of one year (July 2013 to June 2014) were randomly divided into two therapeutic groups. Patients in group 1 (24 patients in total) and group 2 (23 patient in total) were treated with glutamine-supplemented TPN and standard TPN respectively. Patients were assessed for nutritional parameters, the prevalence of complications, mortality, length of hospital stay (LOS) and length of TPN.

RESULTS: The majority of patients were male in both groups (62.5% in group 1 and 60.9% in group 2) and the average age was similar (39.13±4.46 years in group 1 and 40±3.96 years in group 2). The major causative factor was also similar in both groups, i.e. gall stones. The prevalence of complications in the group 2 was much higher (47.85%) than those in the group 1 (25%). The mortality rate for group 1 and 2 were 4.2% (1/24) and 17.4% (4/23), respectively. The length of hospital stay in the group 2 (23.08 ± 2.02 days) was longer than those of the group 1 (20.33 ± 2.40 days). The length of TPN was also longer in the group 2 (16.47 ± 2.72 days) than those of the group 1 (10.56 ± 2.21 days). Glutamine was also associated with significant increase in serum albumin level.

CONCLUSIONS: Glutamine-supplemented TPN can reduce the mortality and the occurrence of complications, shorten the length of stay and improve the nutritional status of the patients with severe acute pancreatitis.

Free PDF Download