Eur Rev Med Pharmacol Sci 2016; 20 (19): 4082-4088

Roles of PECAM-1 in cell function and disease progression

Y.-M. Feng, X.-H. Chen, X. Zhang

Department of Hematology, Second Affiliated Hospital, Third Military Medical University, Chongqing, China. yimeifeng@163.com

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) belongs to immunoglobulin superfamily, which is key factor for adhesion and accumulation of platelets. It is proved that PECAM-1 is closely correlative with cell migration, proliferation, apoptosis, signal transduction and cellular immunity. Meanwhile, PECAM-1 involves in multiple clinical diseases, such as atherosclerosis, thrombosis and leukemia. This paper reviewed the structure and function of PECAM-1, and its roles in cell function and disease generation and progression.

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To cite this article

Y.-M. Feng, X.-H. Chen, X. Zhang
Roles of PECAM-1 in cell function and disease progression

Eur Rev Med Pharmacol Sci
Year: 2016
Vol. 20 - N. 19
Pages: 4082-4088

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