Expressions of serum inflammatory cytokines and their relationship with cerebral edema in patients with acute basal ganglia hemorrhage

X.-M. Wang, Y.-G. Zhang, A.-L. Li, Z.-H. Long, D. Wang, X.-X. Li, J.-H. Xia, S.-Y. Luo, Y.-H. Shan

Department of Critical Care, Zhumadian Central Hospital, Zhumadian, Henan Province, China. gkxio836@sina.com

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• Neurology

OBJECTIVE: The aim of the present study is to investigate expressions of inflammatory cytokines and their relationship with cerebral edema in the patients with acute basal ganglia hemorrhage.

PATIENTS AND METHODS: Between January 2015 and March 2016, 94 patients with acute basal ganglia hemorrhage admitted to our institution were included in the present study. Serum levels of interleukin (IL)-4, IL-6, IL-8 and IL-10 were measured using enzyme-linked immunosorbent assay (ELISA), and conditions of cerebral edema were evaluated using head CT upon admission, 1d after admission and 3d after admission, respectively.

RESULTS: Serum levels of IL-4, IL-6 and IL-8 peaked 1d after admission and decreased 3d after admission with statistical significance (p <0.05); the IL-10 level was continuously increased after admission and peaked 3 days after admission with statistical significance (p<0.05). Cerebral edema was not observed in any of these patients upon admission, while occurred with a maximal edema volume 1 day after admission and the volume decreased 3 days after admission with statistical significance (p <0.05). Correlation analysis showed that levels of IL-4, IL-6 and IL-8 were positively correlated with severity of cerebral edema (r=0.324, 0286, 0.305, p <0.05 respectively), whereas IL-10 level was negatively correlated with severity of cerebral edema (r=-0.336, p <0.05).

CONCLUSIONS: Serum levels of IL-4, IL-6 and IL-10 are positively correlated while the IL-10 level is negatively correlated with the severity of the cerebral edema in patients with acute basal ganglia hemorrhage.

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