Intermediate filament Nestin and the cell motility in cancer – a review

A.-M. Shi, Z.-Q. Tao, X. Wang, Y.-Q. Wang

School of Public Health of Nanjing Medical University, Nanjing, China. taoziqi@163.com

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• Oncology

The intermediate filaments (Ifs) constitute the cytoskeleton which is a key feature of both prokaryotic and eukaryotic cells. The IFs are expressed throughout life and are involved in the regulation of cell differentiation, homeostasis, ageing and pathogenesis. The IFs not only provide structural integrity to the cell, but they are involved also in a range of cellular functions from organelle trafficking and cell migration to signaling transduction. The IFs are highly dynamic proteins, able to respond and adapt their network rapidly in response to intra- and extra-cellular cues. In cancer, these IFs play a crucial role with regard to cell invasion vial cell motility. The present review article will enlighten information about important IF nestin with regard to its role in cancer cell motility and invasion.

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