Impairment of time-based prospective memory in patients with Wilson’s disease

T. Dong, J. Qiu, H.-D. Cheng, W.-W. Dong, P. Huang, C.-S. Xu, K. Wang, W.-M. Yang

Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Neuropsychological Laboratory, Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. wangkai1964@126.com

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• Neurology

OBJECTIVE: The aim of this study was to investigate the effect of basal ganglia lesion of Wilson’s disease (WD) patients on event-based prospective memory (EBPM) and time-based prospective memory (TBPM).

PATIENTS AND METHODS: A total of 30 WD patients and 30 age and education level matched healthy controls were included. EBPM (an action whenever particular words were presented) and TBPM (an action at certain times) were performed to test the involvement of the prospective memory in WD.

RESULTS: A significant difference was found in the performance of TBPM (2.9±1.1 vs. 5.8±0.4, p<0.05), but not EBPM (5.4±0.7 vs. 5.5±0.7, p>0.05) in patients with WD compared with the healthy controls.

CONCLUSIONS: Our results demonstrated that basal ganglia are involved in the prospective memory in patients with WD.

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