Long noncoding RNA SNHG15, a potential prognostic biomarker for hepatocellular carcinoma

J.-H. Zhang, H.-W. Wei, H.-G. Yang

Department of Clinical Laboratory, Linyi People’s Hospital, Linyi, Shandong, China. YYLP147@163.com

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• Oncology

OBJECTIVE: The purpose of this study was to investigate the expression of lncRNA SNHG15 and its prognostic value in hepatocellular carcinoma (HCC).

PATIENTS AND METHODS: Expression levels of lncRNA SNHG15 in 152 pairs of HCC tissues and adjacent normal tissues were detected by quantitative real-time PCR. Associations between clinicopathological parameters and lncRNA SNHG15 expression were evaluated using chi-square tests. The overall survival was analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. Univariate and multivariate Cox regression analyses were conducted to determine whether lncRNA SNHG15 was an independent predictor of survival.

RESULTS: The lncRNA SNHG15 expression was significantly upregulated in tumor tissues compared with that in adjacent non-tumor tissues (p < 0.01). It is also proved that lncRNA SNHG15 expression was associated with histological grade (p = 0.000), TNM stage (p = 0.015), and vein invasion (p = 0.000). In addition, Kaplan-Meier analysis showed that increased LncRNA SNHG15 expression was associated with poor overall survival of patients (p = 0.0011). Moreover, the results of the multivariate analysis showed that high lncRNA SNHG15 expression was a significant independent predictor of poor survival in HCC (p < 0.05).

CONCLUSIONS: Our findings suggest that lncRNA SNHG15 may serve as an efficient clinical biomarker and a therapeutic target for HCC patients.

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