Clinical effects of treatment with Tirofiban on patients with high-risk NSTE-ACS after PCI

P. Wei, Y.-J. Huang, X.-H. Zuo, Y.-G. Zhang, Z.-Q. Tao, C.-R. Qiu, Q. Zhang, X.-J. Yang, Q. Fu

Department of Cardiology, Xuzhou Central Hospital, Xuzhou, China. fuqiang@medmail.com.cn

---

• Cardiology

OBJECTIVE: To explore clinical effects of Tirofiban treatment on patients with high-risk non-ST-segment elevation acute coronary syndrome (NSTE-ACS) after percutaneous coronary intervention (PCI).

PATIENTS AND METHODS: 107 patients with high-risk NSTE-ACS after PCI were selected and were divided into two groups. One group of 56 patients was treated with Tirofiban and a second group of 51 patients was taken as control. The occurrence conditions of creatine kinase-myoglobin (CK-MB), cardiac troponin1 (cTnI) level, hemorrhage incidents and major adverse cardiac events (MACE) incidents after treatments were compared.

RESULTS: After 24 h operation, CK-MB and cTnI level in Tirofiban group were both significantly lower than those in control group (p < 0.05), while the difference of hemorrhage incidents between two groups is of no statistical significance (p < 0.05); and the differences in overall occurrence rate of MACE incidents and the occurrence rate of angina pectoris after infarct between two groups were statistically significant (p < 0.05).

CONCLUSIONS: Tirofiban could improve the blood supply condition of hearts of patients with high-risk NSTE-ACS after emergent PCI, lower the occurrence rate of MACE incidents, and decrease the risk of hemorrhage.

Free PDF Download