Treatment of infantile hemangioma by intralesional injection of propranolol combined with compound betamethasone

R.-Z. Shao, D.-H. Zhao, J. Li

Pharmacy Department, Jinan Military General Hospital, Jinan, China. zdhong_003@163.com

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• Pharmacology

OBJECTIVE: To explore the effective and convenient methods of infantile hemangioma treatment.

PATIENTS AND METHODS: From October 2010 to June 2014, 31 infantile hemangioma patients admitted to our hospital, were administered propranolol combined with betamethasone injection treatment of lesions.

RESULTS: All patients were followed for 6 months-2 years. In treated patients, 24 patients with tumor had complete or nearly complete remission while 6 patients showed partial regression. In 1 patient the tumor had no evident change. Adverse reactions of the therapy included local tissue atrophy, ulcer and anorexia, mild diarrhea in the early treatment. Ulcer wound healed after dressing change.

CONCLUSIONS: Treatment of infantile hemangioma lesions with an injection of propranolol combined with betamethasone showed good efficacy. The method is safe and reliable with clear curative effect, convenient, less complicated, and especially suitable for patients with a small area infantile hemangioma.

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