Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines

K. Zandi*§, S. Ahmadzadeh*, S. Tajbakhsh*, Z. Rastian*, F. Yousefi*, F. Farshadpour*, K. Sartavi**

The Persian Gulf Marine Biotechnology Research Center and §The Persian Gulf Tropical and Infectious Disease Research Center, Bushehr University of Medical Sciences, Bushehr (Iran); **Jahad Keshavarzi Research Center, Bushehr (Iran)

---

• Pharmacology

Abstract. – Objectives and Methods: A collection of novel N-hydroxy-3,3-dimethyl-2,6- Abstract. – Background and Objectives: Antitumor drug resistance and side effects of antitumor compounds are the most common problems in medicine. Therefore, finding new antitumor agents with low side effects could be interesting. This study was designed to assay antitumor activity of the extract from brown alga Sargassum oligocystum, gathered from Persian Gulf seashore, against K562 and Daudi human cancer cell lines.
Materials and Methods: The research was performed as an in vitro study. The effect of the alga extract on proliferation of cell lines were measured by two methods: MTT assay and trypan blue exclusion test.
Results and Conclusion: The most effective antitumor activity has been shown at concentrations 500 µg/ml and 400 µg/ml of the alga extract against Daudi and K562 cell lines, respectively. The results showed that the extracts of brown alga Sargassum oligocystum have remarkable antitumor activity against K562 and Daudi cell lines. It is justified to be suggested for further research such as algal extract fractionation and purification and in vivo studies in order to formulate natural compounds with antitumor activities.

Corresponding Author: Keivan Zandi, Ph.D; e-mail: zandi@bpums.ac.ir and keivanzandi@yahoo.com

Free PDF Download