Meta analysis of the association of rs7702187 SNP in SEMA5A gene with risk of Parkinson’s disease

X. Yu, F. Wang, J.-P. Zhang

^{Department of Neurology, Wuxi People’s Hospital Affiliated with Nanjing Medical University, Wuxi, Jiangsu, P.R. China. zhangjianping1a@gmail.com}

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• Neurology

AIM: The aim of our study was to derive a more precise estimation of the association between the SEMA5A rs7702187 polymorphism and the susceptibility for PD by using meta-analysis.

MATERIALS AND METHODS: We searched and collected articles in English or Chinese from the databases of Medline, PubMed, Embase, and Web of Science (updated to September 31, 2010) by using the search terms “semaphorin gene”, “Parkinson’s disease”, “SNPs” and “polymorphism”.

RESULTS: All of these selected studies should meet all of the inclusion criterias such as “case-control studies”, “similar study method”, “sufficient published data for estimating an odds ratio (OR) with 95% confidence interval (CI)”. As a result, 12 studies in different populations including 3539 cases and 3250 controls were selected.

CONCLUSIONS: Our meta-analysis suggests that the Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development in western population (p = 0.20 for heterogeneity, OR = 0.87, 95% CI = [0.79, 0.96]).

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