Interaction relationships of osteoarthritis and rheumatoid arthritis related genes

Q. Zhang, B. Cheng, C.-X. Yang, H.-A. Ge

Orthopedics Department, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China. chengbiaobiao@hotmail.com

 

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• Rheumatology

BACKGROUND: Osteoarthritis (OA), also referred to as degenerative joint disease or wear-and-tear arthritis, is caused by the breakdown of joint cartilage. Rheumatoid arthritis (RA) is a chronic, inflammatory type of arthritis. RA is also classified as a kind of autoimmune disease.

AIM: To find the important genes in RA and OA.

MATERIALS AND METHODS: Comprehensively compared 3 datasets of RA with 2 datasets of OA, 98 genes were sifted. We explored protein-protein associations processed for the 98 genes by mining famous gene/protein interaction/association database.

RESULTS: We found most of those genes appear to play a key role in the anti-inflammatory and immunosuppressive effects.

CONCLUSIONS: Our research would play a useful role in the diagnosis and treatment of OA and RA.

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