Eur Rev Med Pharmacol Sci 2007; 11 (1): 17-20

Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson’s disease in mic

M. Mohanasundari, M. Sabesan

Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamilnadu (India)

The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced astrocyte activation in striatal area induced by MPTP. The results show that HPE has neuromodulating effect against MPTP induced Parkinson’s disease in mice.

Corresponding Author: Muthukumar Sabesan, MD; e-mail: sabesan-muthukumar@yahoo.co.in

Free PDF Download

To cite this article

M. Mohanasundari, M. Sabesan
Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson’s disease in mic

Eur Rev Med Pharmacol Sci
Year: 2007
Vol. 11 - N. 1
Pages: 17-20

Keywords Related articles:

  1. Pharmacological activities of Hypericum scabrum L
  2. Antinociceptive activity and effect of methanol extract of Salvia limbata on withdrawal syndrome in mice
  3. Methanolic extract of Lupinus Termis ameliorates DNA damage in alloxan-induced diabetic mice
  4. Antidepressant-like effect of aqueous extract of Channa striatus fillet in mice models of depression
  5. Curative effect of the egyptian marine Erugosquilla massavensis extract on carbon tetrachloride-induced oxidative stress in rat liver and erythrocytes