Re-analysis of expression profiles for revealing new potential candidate genes of heart failure

H.B. Chen, L. Wang, J.F. Jiang

Department of Medical Cardiology, Tongji Hospital, Affiliated to Tongji University, Shanghai, China. jiangjinfa@sohu.com

 

---

• Cardiology

BACKGROUND: Chronic heart failure (HF) is characterized by diminished cardiac output and pooling of blood in the venous system.

AIM: We used the GSE1145 microarray data to identify potential genes that related to heart failure to construct a regulation network.

MATERIALS AND METHODS: In the network, some of transcription factors (TFs) and target genes have been proved to be related to heart failure in previous study. The gene MYC, RELA, HIF1A, NFκB1 and SMAD3 are as hub nodes in our transcriptional network and have a close relationship with heart failure.

RESULTS: The study did not address regulation network but researched for the significant pathways related to chronic heart failure. Besides, RELA and NFκB1 interfere with each other in response to HF.

CONCLUSIONS: It is demonstrated that transcriptional network analysis is useful in identification of the candidate genes in heart failure.

Free PDF Download