Menstrual changes after COVID-19 vaccine administration: a systematic review

O.E. Santangelo, S. Provenzano, D. Grigis, C. Ferrara, F. Cedrone, A. Firenze

Regional Health Care and Social Agency of Lodi, ASST Lodi, Lodi, Italy. provenzanosandro@hotmail.it

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• Gynecology
• Infectious Diseases

OBJECTIVE: During the mass vaccination campaign for COVID-19, cases of menstrual cycle changes in women emerged, so it was thought that the COVID-19 vaccine could affect the menstrual cycle. Over time, these observations have become more frequent, which strengthens the idea. This systematic review aims to show changes in the menstrual cycle after COVID-19 vaccination.

MATERIALS AND METHODS: This study was carried out following the guidelines of the Cochrane Collaboration and the Meta-analysis of Observational Studies in Epidemiology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes.

RESULTS: A suitable bibliography on PubMed/Medline and Scopus was searched by combining text, words, and titles of medical topics. After completing the search, a total of 42 articles were included in this systematic review.

CONCLUSIONS: The COVID-19 vaccines may have an impact on the quality of life of women. The changes in the menstrual cycle tend to resolve within 2-3 months of vaccination and the symptoms are mild to moderate and tend to self-limit over time.

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