The human microbiota key role in the bone metabolism activity

A.M. Inchingolo, C. Gargiulo Isacco, A.D. Inchingolo, K.C.D. Nguyen, S. Cantore, L. Santacroce, S. Scacco, N. Cirulli, A. Corriero, F. Puntillo, G. Dipalma, A. Ballini, F. Inchingolo

Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy. francesco.inchingolo@uniba.it

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• Pharmacology

Data collection has suggested a complex correlation between the gut microbiota (GM) and bone homeostasis involving host-microbiota crosstalk. Although the GM is known to affect bone metabolism, the mechanisms linked with these effects remain unclear. The aim of this review is to current insight advances regarding how gut-derived hormones regulate bone homeostasis in humans, emphasizing gut-bone axis and bone regeneration. The GM may be engaged in bone metabolism and fracture risk. Additional investigations of the fundamental microbiota-related pathways in bone metabolism may uncover treatment strategies and enable the prevention of osteoporosis. A better knowledge of gut hormones’ action on bone homeostasis may lead to new strategies for preventing and treating skeletal frailty related to age.

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