Investigation of ideal ointment combination to use in septorhinoplasty or nasal flap surgeries

C. Yıldırım, N. Bayar Muluk, M. Kar, F. Kaya, C. Cingi

Department of Medical Pharmacology, Eskisehir Osmangazi University, Hippotherapy Research Center, Eskisehir, Turkey. nbayarmuluk@yahoo.com

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• Otorhinolaryngology

OBJECTIVE: We aimed to create an ideal ointment combination to provide fast wound healing with the highest patient comfort after nasal surgery and nasal flap surgery.

MATERIALS AND METHODS: Twenty-one male Wistar rats were included. The flap survival method was used. The rats’ healing process was evaluated in all groups. After having the same surgical procedure, the following ointments were applied to flap borders twice a day for seven days in each of the groups. In group 1 (Control, n=7), Dexpanthenol 5% (Dex); in group 2, Dex, Ciprofloxacin 0.5 % (Cip) and Ephedrine hydrochloride 1% (Eph); in group 3, Dex+Cip+Eph and Ketoprofen 2.5% (Ket) was applied. On the seventh postoperative day, the size of the necrosis on the flap was evaluated.

RESULTS: Median necrotic areas on skin flaps were 36.00% sq mm in group 1, 23.00% sq mm in group 2, and 5.00% sq mm in group 3. Flap necrosis areas on skin flaps were group 3 <group 2 <group 1 (p adjusted <0.0175). The necrosis areas of groups 2 and 3 were significantly lower than the control group, and the necrosis areas of group 3 were significantly lower than group 2 (p adjusted <0.0175).

CONCLUSIONS: For the postoperative healing process and to prevent flap necrosis, the Dex+Cip+Eph+Ket combination was recommended in the first order. Dex+Cip+Eph combination also reduced skin necrosis in the flaps as the second order. Only Dex treatment is not enough for the completion of the healing process. The best results were provided by the Dex+Cip+Eph+Ket combination and recommended its usage after septorhinoplasty surgeries or nasal flap surgeries to prevent flap necrosis.

Published on: 2022/12/07

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