Quantitative analysis of gastrointestinal bleeding with technetium-99m–labeled red blood cells in an experimental model

X. Yuan, J. Sun, J. Yu, Y.-P. Zhao

Department of Nuclear Medicine, Second Affiliated Hospital of Dalian Medical University, Dalian, China. 13941156265@163.com

 

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• Gastroenterology

OBJECTIVE: The aim of this study was to propose a quantitative analysis method using technetium (Tc)-99m-labeled red blood cell RBC imaging to allow calculation of the amount and the rate of gastrointestinal (GI) bleeding.

MATERIALS AND METHODS: Rabbit models of fixed-GI and continuous-GI bleeding were created using catheter infusion. The amount and rate of bleeding were calculated and compared with the infused amount and rate.

RESULTS: No significant differences in calculated or actual amounts or rates of GI bleeding were observed after 2, 4, and 6 hours of catheter infusion of Tc-99m-RBCs.

CONCLUSIONS: The proposed quantitative analysis method using Tc-99m-RBCs GI scintigraphy can accurately calculate the actual amount and rate of GI bleeding.

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