Eur Rev Med Pharmacol Sci 2020; 24 (18): 9591-9600
DOI: 10.26355/eurrev_202009_23047

Metabolomics and its application in the mechanism analysis on diabetic bone metabolic abnormality

W.-D. Liang, P.-J. Huang, L.-H. Xiong, S. Zhou, R.-Y. Ye, J.-R. Liu, H. Wei, R.-Y. Lai

Department of Endocrinology, Dongguan Hospital of Traditional Chinese Medicine, Dongguan, China. 13688857425@163.com


OBJECTIVE: This study is aimed at analysing the endogenous metabolites profiling of patients with diabetic osteoporosis, so as to provide the reference for pathogenesis research of diabetic osteoporosis.

PATIENTS AND METHODS: The 1H-NMR metabolomics technology, combined with pattern recognition analysis and SIMCA-P 12.0 statistical analysis, were employed to identify the metabolites differences between diabetic patients with disordered bone metabolism (research group) and healthy volunteers (normal group) in this study.

RESULTS: Compared with normal group, the results show that in research group, the levels of O-acetyl glycoprotein, proline, 1-methyl histidine, tricarboxylic acid cycle (TCA cycle) product (citric acid and α-ketoglutaric acid) decline, while the levels of branched chain amino acids (leucine, isoleucine, valine), glucose, choline, creatine, inositol, glutamine, aspartic acid, alanine, glycine, and citrulline increase.

CONCLUSIONS: There are disordered metabolic pathways and imbalanced bone synthetic materials and regulatory substances in diabetic patients with bone metabolic abnormality. These metabolic abnormalities could be the specific indicators in early diagnosis of diabetic osteoporosis.

 

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To cite this article

W.-D. Liang, P.-J. Huang, L.-H. Xiong, S. Zhou, R.-Y. Ye, J.-R. Liu, H. Wei, R.-Y. Lai
Metabolomics and its application in the mechanism analysis on diabetic bone metabolic abnormality

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 18
Pages: 9591-9600
DOI: 10.26355/eurrev_202009_23047