Correlation between MRAS gene polymorphism and atherosclerosis

Z.-Y. Wu, Z.-G. Wu, H.-M. Qi, Z.-T. Chang, Y.-Z. Zhou, L. Hong

Department of Cardiology, Jiangxi Provincial People’s Hospital, Jiangxi Provincial Cardiovascular Disease Institute, Nanchang, China. nadinewzg@163.com

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• Cardiology

OBJECTIVE: The aim of this study was to explore the correlation between muscle RAS oncogene homolog (MRAS) gene polymorphism and the onset risk of atherosclerosis (AS).
PATIENTS AND METHODS: A total of 135 AS patients diagnosed and treated in our hospital from November 2017 to October 2018 were randomly enrolled in the observation group. Meanwhile, 150 healthy adults were selected as control group. Venous blood was withdrawn from all the subjects, and DNAs were extracted. MRAS gene loci rs9818870 and rs3755751 were analyzed by the multiplex SNaPshot method, and their correlations with the onset risk of AS were explored.
RESULTS: No statistically significant differences in the frequencies at gene loci were observed between the two groups (p>0.05). Subjects with genotype TT at rs9818870 exhibited significantly higher risk of AS (p=0.041<0.05). The recessive model of rs9818870 (GG + AG/AA) in AS patients with coronary heart disease was correlated with AS (p=0.048<0.05). Similarly, the dominant model of rs3755751 (TT/TC+CC) in those with hypertension was associated with AS (p=0.027<0.05).
CONCLUSIONS: MRAS gene is correlated with the onset of AS to a certain degree.

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