Clinical significance of lncRNA BCYRN1 in colorectal cancer and its role in cell metastasis

J.-H. Yu, Y. Chen

Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, Jilin, China. c_y@jlu.cn

---

• Oncology

OBJECTIVE: To explore the expression of long non-coding RNA (lncRNA) BCYRN1 and its clinical significance and function in colorectal cancer (CRC).

PATIENTS AND METHODS: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to detect the expression of lncRNA BCYRN1 in CRC tissues and cells. The relationship between lncRNA BCYRN1 expression and CRC clinicopathological characteristics was statistically analyzed. Furthermore, the Kaplan-Meier curve was performed in survival analysis. In vitro study, transwell and Western blot assays were used to detect the metastasis ability of CRC cells.

RESULTS: LncRNA BCYRN1 expression was markedly up-regulated in CRC; high expression of lncRNA BCYRN1 promoted tumor metastasis in CRC patients and suggested a poor prognosis. In vitro study, down-regulation of lncRNA BCYRN1 expression by si-BCYRN1 could significantly inhibit invasion and migration of CRC cells.

CONCLUSIONS: LncRNA BCYRN1 was a novel factor involved in CRC progression, and constituted a potential biomarker and therapeutic target for the patients.

Free PDF Download