Current views of chromosomal abnormalities in pediatric acute myeloid leukemia (AML)

L.-H. Shi, P. Ma, J.-S. Liu, Y. Li, Y.-F. Wang, M.-F. Guo, W. Liu

Henan Medical Key Laboratory of Pediatric Hematology, Children’s Hospital of Zhengzhou, Henan, China. amelia365@163.com

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• Pediatrics

Chromosomal abnormalities are an attractive avenue for the screening of various disorders especially related to carcinogens like acute myeloid leukemia (AML). The cytogenetic findings like Karyotypic patterns are common in pediatric patients. On the other hand, monosomal karyotype (MK) and complex karyotype (CK) are more common in older patients. Further, recent studies have revealed direct proportion between the number of chromosome abnormalities and mortality rates in both pediatric as well as old patients affected by AML. Moreover, to be specific 5q, 7q and/or 17p loss lead to higher mortality rates in comparison to loss of to MK.  The present review article would put light on current views of important chromosomal changes during AML, especially in pediatric patients.

Published on: 2017/10/25

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