Long non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer

Y. Chen, C.-X. Wang, X.-X. Sun, C. Wang, T.-F. Liu, D.-J. Wang

Department of Obstetrics and Gynecology, Linyi People’s Hospital, Linyi, Shandong, China. ddmini2@sina.com

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• Oncology

OBJECTIVE: Our study is intended to explore the correlation of long non-coding RNA CCHE1 (CCHE1) and clinicopathological factors of cervical cancer patients, and evaluate the impact of CCHE1 on the prognosis of cervical cancer.

PATIENTS AND METHODS: The CCHE1 expression in cervical cancer tissues was examined by quantitative Real-time PCR (qRT-PCR) and its correlation with clinicopathological features was also analyzed. A Kaplan-Meier survival curve was generated following a log-rank test. Multivariate Cox regression analyses were finally used to determine the independent factors for overall survival (OS) and recurrence-free survival (RFS) times.

RESULTS: Our results showed that higher CCHE1 expression was found in cervical cancer tissues compared with the match normal cervical tissues. Then, we found that high levels of CCHE1 expression correlated with FIGO stage (p= 0.014), tumor size (p = 0.007), lymph node metastasis (p = 0.022) and HPV (p = 0.001). Results of Kaplan-Meier survival curve revealed that patients with low CCHE1 expression had better OS (p = 0.019) and RFS (p = 0.006) than patients with high CCHE1 expression. Finally, overexpression of CCHE1 was supposed to be an independent poor prognostic factor for predicting the 5-year RFS and OS of cervical cancer patients through multivariate analysis.

CONCLUSIONS: Increased CCHE1 was associated with poor survival in cervical cancer patients, suggesting that CCHE1 was a potential prognostic biomarker for cervical cancer.

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