Eur Rev Med Pharmacol Sci 2017; 21 (1): 68-75

Breast cancer metastasis suppressor 1 (BRMS1) suppresses prostate cancer progression by inducing apoptosis and regulating invasion

H.-M. Zhang, Q.-D. Qiao, H.-F. Xie, J.-X. Wei

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. lchlv439@sina.com

OBJECTIVE: Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as a metastasis suppressor gene in human breast cancer.

MATERIALS AND METHODS: A recent study has established an association between BRMS1 with the clinical stage and different pathology grades of prostate cancer. However, whether BRMS1 plays a role in prostate cancer has not been elucidated.

RESULTS: In this study, we found that overexpression of BRMS1 in PC-3 cells induced apoptosis and inhibited invasion; moreover, we found that overexpression BRMS1 was associated with the suppressed expression of EMMPRIN.

CONCLUSIONS: Taken together, our results show that BRMS1 may suppress progression and metastasis of prostate cancer through modulating EMMPRIN expression.

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To cite this article

H.-M. Zhang, Q.-D. Qiao, H.-F. Xie, J.-X. Wei
Breast cancer metastasis suppressor 1 (BRMS1) suppresses prostate cancer progression by inducing apoptosis and regulating invasion

Eur Rev Med Pharmacol Sci
Year: 2017
Vol. 21 - N. 1
Pages: 68-75

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