Downregulation of miR-145-5p correlates with poor prognosis in gastric cancer

Y. Zhang, X. Wen, X.-L. Hu, L.-Z. Cheng, J.-Y. Yu, Z.-B. Wei

Department of Oncology, Heping Hospital, Changzhi Medical College, Changzhi, Shanxi, P.R. China. weiw5m@sina.com

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• Oncology

OBJECTIVE: The aim of this study was to explore the clinical significance of miR-145-5p expression in gastric cancer (GC).

PATIENTS AND METHODS: Expression of miR-145-5p was evaluated by qRT- PCR in tumor and normal gastric tissues in 145 GC patients. The correlation between the miR-145-5p expression and clinicopathological parameters was investigated. Finally, the survival was assessed by the Kaplan-Meier method and proportional hazards model.

RESULTS: Expression levels of miR-145-5p in GC tissues were significantly lower than those in adjacent normal tissues (p < 0.001). MiR-145-5p expression was significantly associated with lymph node metastasis, metastasis stage, and distant metastasis (all p < 0.05). Furthermore, Patients with low miR-145-5p expression had poorer overall survival time than those with high miR-145-5p expression (p = 0.014).
Moreover, univariate and multivariate Cox analysis showed that miR-145-5p was an independent prognostic indicator for OS (p = 0.011).

CONCLUSIONS: MiR-145-5p is down-expressed in GC, and can be used as a marker of poor prognosis in GC patients.

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