Eur Rev Med Pharmacol Sci 2016; 20 (8): 1474-1478

Expression level of NSE, S100B and NPY in children with acute miliary phthisis and secondary tubercular meningitis

C.-X. Zhang, D.-J. Zhang, Y.-L. Wang, W. Han, G.-C. Shi, H.-Q. Zhang

The First Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China. lafhjg@163.com


OBJECTIVE: To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis.

PATIENTS AND METHODS: 28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C. The levels of NSE, S100B and NPY in cerebrospinal fluid and serum were detected.

RESULTS: The levels of NSE, S100B and NPY in cerebrospinal fluid and serum of group A were significantly higher than the levels in the other two groups, differences were statistically significant (p<0.05). A multifactor retrospective analysis suggested that secondary tubercular meningitis was significantly correlated with the high expression of S100B, NPY and NSE in cerebrospinal fluid and serum.

CONCLUSIONS: Early detection of the expression levels of NSE, S100B and NPY in cerebrospinal fluid and serum was of great value for the diagnosis of tubercular meningitis secondary to acute miliary tuberculosis.

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To cite this article

C.-X. Zhang, D.-J. Zhang, Y.-L. Wang, W. Han, G.-C. Shi, H.-Q. Zhang
Expression level of NSE, S100B and NPY in children with acute miliary phthisis and secondary tubercular meningitis

Eur Rev Med Pharmacol Sci
Year: 2016
Vol. 20 - N. 8
Pages: 1474-1478